Understanding immune cell differences in ALS
Defining Immune Cell Heterogeneity in Human ALS and Mouse Model of the Disease
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10824326
This study is looking at how immune cells affect ALS, a serious disease that impacts movement, by examining samples from people with ALS and mice to find ways to create better treatments that could slow down the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10824326 on ClinicalTrials.gov |
What this research studies
This research investigates the role of immune cells in amyotrophic lateral sclerosis (ALS), a severe motor neuron disease. By analyzing immune cells from both human patients and a mouse model, the study aims to identify specific immune responses that contribute to the disease. Using advanced techniques like single-cell RNA sequencing, researchers will explore the genetic signatures of these immune cells to develop targeted therapies that could modify the disease's progression. The ultimate goal is to find biomarkers that can lead to more effective treatments for ALS.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with amyotrophic lateral sclerosis (ALS).
Not a fit: Patients with other neurological disorders or those who do not have ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the immune response in ALS, potentially slowing disease progression and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting immune responses in neurodegenerative diseases, suggesting that this approach may yield beneficial results.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRZEDBORSKI, SERGE E — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: PRZEDBORSKI, SERGE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease, Lou Gehrig Disease