Understanding immune cell behavior in brain cancer patients
Proj. 3: Immunosuppressive circuits in T cells and other immune cells in GBM patients enrolled in clinical trials
['FUNDING_P01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10876411
This study is looking at how certain immune cells called T cells work in people with glioblastoma, a type of brain cancer, to find out which genes might be stopping the immune system from fighting the tumors, with the hope of improving cancer treatments for patients in a clinical trial.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10876411 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune cells, specifically T cells, function in patients with glioblastoma (GBM), a type of brain cancer. By analyzing genetic data from these T cells, the researchers aim to identify specific genes that may inhibit the immune response against tumors. The study will focus on patients enrolled in a clinical trial receiving a specific treatment, examining how these immune cells interact with tumor cells. The goal is to uncover mechanisms that could enhance the effectiveness of cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are participating in clinical trials.
Not a fit: Patients with other types of cancer or those not enrolled in relevant clinical trials may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by enhancing the immune response against glioblastoma.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses in cancer through similar approaches, indicating potential for success in this study.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WUCHERPFENNIG, KAI W — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: WUCHERPFENNIG, KAI W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.