Understanding immune cell and fibroblast behavior in inflamed tissues of rheumatoid arthritis and lupus
Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE
This study is looking at how certain immune cells behave in the tissues of people with rheumatoid arthritis and lupus, to better understand what causes ongoing inflammation and to help develop more effective treatments, and patients can get involved by sharing samples or taking part in related assessments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064776 on NIH RePORTER |
What this research studies
This research investigates how immune cells and fibroblasts behave in inflamed tissues specifically affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). By analyzing the interactions between T and B cells that lead to the production of autoantibodies, the study aims to identify specific cell populations that contribute to chronic inflammation in these diseases. Using advanced techniques like single-cell RNA sequencing and CyTOF analysis, researchers will explore the unique characteristics of immune cells in the affected tissues, which could lead to better-targeted therapies. Patients may have the opportunity to contribute to this research by providing samples or participating in related clinical assessments.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with rheumatoid arthritis or systemic lupus erythematosus.
Not a fit: Patients with other autoimmune diseases not related to RA or SLE may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from rheumatoid arthritis and lupus by identifying new therapeutic targets.
How similar studies have performed: Previous research has shown promise in understanding immune mechanisms in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brenner, Michael B. — Brigham and Women's Hospital
- Study coordinator: Brenner, Michael B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.