Understanding immune activation in women with HIV
CD38 intensifies immune activation in women living with HIV (the CIGNAL study)
['FUNDING_R21'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11138596
This research looks at why women living with HIV might experience more immune system overactivity, even with treatment, compared to men.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11138596 on ClinicalTrials.gov |
What this research studies
We know that women living with HIV often face more health challenges and faster disease progression than men, even when taking effective medication. This difference may be linked to ongoing immune system activation, which means the body's defenses are constantly working overtime. This project aims to understand how a specific marker called CD38 on immune cells might contribute to this overactivity in women. By understanding these differences, we hope to find new ways to help women living with HIV.
Who could benefit from this research
Good fit: This research is relevant for adult women aged 21 and older who are living with HIV and receiving antiretroviral therapy.
Not a fit: Patients who are not living with HIV or who are men would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target immune activation in women living with HIV, potentially improving their long-term health and quality of life.
How similar studies have performed: While the role of immune activation in HIV is known, this specific focus on sex-specific differences and CD38 as a therapeutic target in women living with HIV represents a novel approach.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATHUR, POONAM — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MATHUR, POONAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus