Understanding immature tumor cells in pediatric rhabdomyosarcoma
Official title: The Role of Immature Tumor Subpopulations In Pediatric Rhabdomyosarcoma
Funded at St. Jude Children's Research Hospital · NIH-11031369 · Data updated 2026-11-12
This study is looking at how certain early-stage cells in rhabdomyosarcoma, a cancer that mainly affects kids, behave during treatment to help understand why some children might have their cancer come back, with the hope of creating better, personalized treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | March 4, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $416,325 |
| NIH project number | 5R01CA262790-04 |
| Project ID | NIH-11031369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with rhabdomyosarcoma, particularly those who have undergone treatment and are at risk of recurrence.
✕Less likely to help
Patients with other types of cancer or those who are not diagnosed with rhabdomyosarcoma may not benefit from this research.
What this research studies
This research investigates the role of immature tumor subpopulations in rhabdomyosarcoma, a type of cancer that primarily affects children. The team will analyze tumor samples using advanced computational methods to identify different cell types within the tumors and their genetic characteristics. By studying how these immature cells behave during and after treatment, the researchers aim to uncover why some patients experience cancer recurrence. This knowledge could lead to the development of more effective therapies tailored to individual patient needs.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce the risk of cancer recurrence in pediatric patients with rhabdomyosarcoma.
How similar studies have gone: Other research has shown promise in understanding tumor heterogeneity and its implications for treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Chen, Xiang — St. Jude Children's Research Hospital
- Study coordinator: Chen, Xiang
Related research
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A project to understand why a pediatric muscle cancer called rhabdomyosarcoma spreads, and to test ideas that could slow or stop it by helping cancer cells mature properly.
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Understanding infantile rhabdomyosarcoma biology and new treatment targets
A new grant is studying why infantile rhabdomyosarcoma develops and what drugs or strategies could specifically target it in young children.
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Targeting CLK2 to Fight Rhabdomyosarcoma
Aims to see if blocking CLK2 can weaken rhabdomyosarcoma cancer cells, potentially offering a new treatment for kids and young adults.
-
Epitranscriptomic Crosstalk in Alveolar Rhabdomyosarcoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.