Understanding IDH Mutations in Cancers
Isocitrate dehydrogenase (IDH) mutations as drivers of organelle stress and dysfunction
This work explores how specific changes in IDH proteins contribute to certain cancers, including brain tumors and leukemia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11083324 on NIH RePORTER |
What this research studies
Our bodies have proteins called IDH1 and IDH2 that normally help with important cell processes. However, when these proteins have certain changes, or mutations, they can lead to the production of a harmful substance that promotes cancer growth. These IDH mutations are found in many lower-grade brain tumors, bone cancers, and a type of blood cancer called acute myeloid leukemia. While some treatments already exist, we still need to learn more about how these mutated IDH proteins work. This research aims to uncover the key features of these disease-causing IDH mutations to better understand their role in cancer.
Who could benefit from this research
Good fit: Patients with cancers such as lower-grade gliomas, chondrosarcomas, or acute myeloid leukemia that are known to have IDH mutations might benefit from future treatments developed from this research.
Not a fit: Patients whose cancers do not involve IDH mutations are unlikely to directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and targeted treatments for cancers driven by IDH mutations.
How similar studies have performed: While FDA-approved inhibitors for IDH-mutated cancers exist, this research delves into fundamental questions about how these mutations work, which are not yet fully understood.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Sohl, Christal Dyane — San Diego State University
- Study coordinator: Sohl, Christal Dyane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.