Understanding Huntington's Disease Using a Marmoset Model
Correlating molecular behavioral phenotypes in a marmoset model of Huntingtons disease
['FUNDING_U01'] · ROCKEFELLER UNIVERSITY · NIH-11092277
This project aims to create a new primate model to better understand Huntington's disease and develop future treatments.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11092277 on ClinicalTrials.gov |
What this research studies
Researchers are working to create a special marmoset model that closely mimics Huntington's disease in humans. This involves using advanced genetic tools to introduce specific changes in the marmosets' genes, similar to how the disease develops in people. By studying these marmosets, we hope to learn more about the disease's effects on behavior and the brain. This new model could help us discover new ways to treat Huntington's disease in the future.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future clinical trials stemming from this work would target individuals with Huntington's disease.
Not a fit: Patients without Huntington's disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a more accurate animal model for Huntington's disease, accelerating the discovery and testing of new therapies for patients.
How similar studies have performed: While CRISPR/Cas9 has been used in marmosets for simpler genetic changes, creating complex, heritable models for diseases like Huntington's has been a significant challenge, making this approach novel in primates.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRIVANLOU, ALI H — ROCKEFELLER UNIVERSITY
- Study coordinator: BRIVANLOU, ALI H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.