Understanding huntingtin proteins in cerebrospinal fluid for Huntington's disease
Decoding cerebrospinal fluid huntingtin biomarkers
This study is looking at a protein called huntingtin in the fluid around your brain to see how it can help us understand Huntington's disease better and find out if new treatments can lower harmful protein levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-10825623 on NIH RePORTER |
What this research studies
This research aims to measure the levels of huntingtin protein in cerebrospinal fluid (CSF) to better understand its role as a biomarker for Huntington's disease. By analyzing how this protein behaves in the brain and CSF, researchers hope to determine how effective treatments can be in reducing harmful protein levels. The study involves comparing different brain regions and cell types to see how they contribute to the levels of huntingtin in the CSF. This information could help predict the effects of new therapies on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease who are undergoing treatment.
Not a fit: Patients without a diagnosis of Huntington's disease or those who are not receiving treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with Huntington's disease.
How similar studies have performed: Previous studies have shown promise in using cerebrospinal fluid biomarkers for monitoring Huntington's disease, indicating that this approach has potential for success.
Where this research is happening
Orlando, United States
- University of Central Florida — Orlando, United States (Active)
Researchers
- Principal investigator: Southwell, Amber L — University of Central Florida
- Study coordinator: Southwell, Amber L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.