Understanding human nerve cells involved in pain and injury
Characterization of human DRG at the single cell level via integrated transcriptomics and spatial proteomics
This study is looking at how pain and nerve injuries work at a tiny level by examining cells from the spinal nerves of organ donors, which could help us find better ways to treat pain and nerve problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10930009 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms of pain and nerve injury by studying human dorsal root ganglia (DRG) at a single-cell level. The team will extract human DRG from organ donors and analyze the cells using advanced techniques like single-cell sequencing and imaging mass cytometry. This approach allows for a detailed understanding of both neuronal and non-neuronal cells, which is crucial for developing effective treatments for pain and peripheral neuropathies. By integrating gene expression data with protein markers, the research aims to provide insights that could lead to better therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who experience acute pain or have suffered nerve injuries.
Not a fit: Patients with conditions unrelated to nerve function or pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic pain and nerve injuries.
How similar studies have performed: Previous research using rodent models has shown promise, but this study aims to validate findings specifically in human tissues, making it a novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cavalli, Valeria — Washington University
- Study coordinator: Cavalli, Valeria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.