Understanding human evolutionary history and genetic diversity
Official title: Population genetics of human evolutionary history and natural selection
Funded at University of Wisconsin-Madison · NIH-11143131 · Data updated 2026-11-12
This study looks at how our genes have changed over time due to natural selection and aims to help us understand the history of human populations and how our genetic differences can impact health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $375,430 |
| NIH project number | 5R35GM154962-02 |
| Project ID | NIH-11143131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals from diverse ethnic backgrounds who are interested in the genetic factors affecting their health.
✕Less likely to help
Patients with no interest in genetic research or those from highly homogeneous populations may not receive significant benefits from this research.
What this research studies
This research investigates the complex history of human populations and how natural selection has shaped our genetic makeup. It focuses on three main areas: uncovering the structure of human populations over time, understanding the factors that influence genetic selection, and modeling the genetic basis of complex traits. By analyzing extensive genome sequencing data from diverse populations, the research aims to reveal insights into our evolutionary past and the genetic variations that affect health and disease. This work combines theoretical, statistical, and empirical methods to enhance our understanding of human genetics.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors influencing health and disease susceptibility in different populations.
How similar studies have gone: Previous research in population genetics has shown success in uncovering important insights into human evolution and genetic diversity, indicating that this approach is both valid and promising.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Ragsdale, Aaron — University of Wisconsin-Madison
- Study coordinator: Ragsdale, Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.