Understanding human development through gene regulation in mice
Modeling uniquely human developmental gene regulatory networks using humanized mice
This study is looking at how certain genetic changes that happened as humans evolved affect our growth and abilities, using specially designed mice to help understand these unique human genes and what they do for us.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10814908 on NIH RePORTER |
What this research studies
This research investigates how specific genetic changes that occurred during human evolution influence our development. By using humanized mice, the team aims to model and study gene regulatory networks that are unique to humans, focusing on elements that have evolved to enhance our physical and cognitive traits. The project examines two types of gene regulatory elements, Human Accelerated Regions and Human Gain Enhancers, to uncover their roles in developmental processes. This approach allows researchers to explore the biological functions of these genes and their impact on human morphology.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions that affect development or morphology.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by developmental gene changes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of human development and the genetic basis of certain human traits.
How similar studies have performed: Previous research has shown success in using animal models to study gene regulation and its effects on development, making this approach promising.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Noonan, James P — Yale University
- Study coordinator: Noonan, James P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.