Understanding human centromeres and their role in chromosome segregation
Human centromere variation and function
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10994620
This study is looking at the important parts of our chromosomes called centromeres to see how they differ among people and how these differences might affect cell division, which is key to preventing issues like birth defects and cancer, so that we can learn more about how to help patients in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10994620 on ClinicalTrials.gov |
What this research studies
This research investigates the structure and function of human centromeres, which are crucial for the accurate segregation of chromosomes during cell division. By using advanced long-read sequencing technologies, the study aims to uncover the natural variation of centromeres across diverse human populations. It will also explore how this variation impacts chromosome segregation, which is essential for preventing conditions like aneuploidy, birth defects, and cancer. Patients may benefit from insights gained into the genetic and epigenetic factors that influence these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of chromosomal abnormalities, birth defects, or cancer.
Not a fit: Patients who do not have any known chromosomal issues or related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of conditions related to chromosome segregation errors, such as certain cancers and birth defects.
How similar studies have performed: Other research has shown promising results in understanding chromosome behavior and its implications for health, making this approach both relevant and potentially impactful.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOGSDON, GLENNIS AMELIA — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LOGSDON, GLENNIS AMELIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.