Understanding HPV and body factors in childhood respiratory growths
HPV and host factors in juvenile onset recurrent respiratory papillomatosis
This project looks at how HPV and a child's own body factors cause recurring growths in the breathing passages, hoping to find new ways to help children with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11132991 on NIH RePORTER |
What this research studies
Children with juvenile-onset recurrent respiratory papillomatosis (JoRRP) often experience recurring growths in their airways, requiring many surgeries and greatly affecting their quality of life. This important work aims to understand why these growths happen and why their severity varies so much among children. Researchers are using special 3D models created from tissue samples donated by children with JoRRP to study how the HPV virus interacts with the body's cells. By looking closely at the genetic activity in these cells, they hope to uncover new clues about the disease. The goal is to identify specific markers and targets that could lead to more effective treatments and better ways to predict how the disease will progress.
Who could benefit from this research
Good fit: This research is focused on understanding juvenile-onset recurrent respiratory papillomatosis (JoRRP) in children, particularly those aged 0-11 years who have experienced these recurring growths.
Not a fit: Patients without juvenile-onset recurrent respiratory papillomatosis would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new medications and better ways to predict the course of juvenile-onset recurrent respiratory papillomatosis, reducing the need for frequent surgeries in children.
How similar studies have performed: While the specific approach of using internally controlled 2D/3D models from patient tissue is advanced, previous research has shown the value of studying viral and host factors in other diseases.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Wells, Susanne I — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Wells, Susanne I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.