Understanding how ZNF804A affects brain development and mental health.
Translational control in neurogenesis by ZNF804A
This study is looking at how a gene called ZNF804A affects brain development and its link to mental health issues like schizophrenia and bipolar disorder, hoping to find out how problems with this gene might lead to challenges in behavior for young people and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-10806931 on NIH RePORTER |
What this research studies
This research investigates the role of the ZNF804A gene in brain development and its connection to mental health disorders like schizophrenia and bipolar disorder. By examining how ZNF804A influences the production and differentiation of neural progenitor cells, the study aims to uncover the molecular mechanisms that may lead to behavioral deficits in adolescents and adults. The approach includes genetic analysis and neuroimaging to explore the impacts of ZNF804A dysfunction on brain structure and connectivity. This research could provide insights into the biological underpinnings of these mental illnesses and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 12 and older who are affected by schizophrenia or bipolar disorder.
Not a fit: Patients with mental health disorders unrelated to the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating mental health disorders in adolescents and adults.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of mental health disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Mao, Yingwei — Pennsylvania State University, the
- Study coordinator: Mao, Yingwei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.