Understanding how ZIP transporters manage essential metals in the body
Transport, substrate specificity and regulation mechanisms of the ZIP transition metal transporters
This study is looking at how certain proteins in our bodies help manage important metals like zinc, which is crucial for our health, and it aims to understand how these proteins work to keep our metal levels balanced and prevent any harmful buildup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11077248 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which ZIP transporters regulate the transport and distribution of essential transition metals like zinc in the human body. It aims to clarify how these transporters function at a molecular level, focusing on their role in maintaining zinc homeostasis and their involvement in the metabolism of other metals. By studying the structural and regulatory aspects of these transporters, the research seeks to uncover how they contribute to cellular processes and prevent toxicity from metal overload. This work could provide insights into the biological significance of these transporters in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metal metabolism, such as zinc deficiency or overload disorders.
Not a fit: Patients with conditions unrelated to metal transport or metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of metal-related diseases and potential therapeutic strategies for conditions linked to metal imbalances.
How similar studies have performed: Previous research has shown success in understanding the roles of metal transporters in various biological processes, indicating that this approach is grounded in established scientific principles.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Hu, Jian — Michigan State University
- Study coordinator: Hu, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.