Understanding how zinc finger proteins interact with hydrogen sulfide signaling
The Role of Zinc Fingers in H2S Signaling
This study is looking at how a special type of protein called zinc finger proteins interacts with hydrogen sulfide, a gas that helps our bodies work properly, to see how it might affect important processes like inflammation and metabolism, which could help us understand diseases like heart and brain conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10728360 on NIH RePORTER |
What this research studies
This research investigates the role of zinc finger (ZF) proteins in the signaling process of hydrogen sulfide (H2S), a gasotransmitter that plays a crucial role in various biological functions. The study aims to uncover how H2S modifies ZF proteins through a process called persulfidation, which may influence cell signaling related to inflammation, metabolism, and other critical functions. By analyzing the interactions between H2S and ZF proteins, the research seeks to clarify the mechanisms behind H2S signaling and its implications for diseases such as cardiovascular and neurological disorders. This could lead to a better understanding of how these proteins function in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular, neurological, inflammatory, or metabolic diseases that may be influenced by H2S signaling.
Not a fit: Patients without any of the aforementioned conditions or those not affected by H2S signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into new therapeutic targets for treating diseases linked to abnormal H2S signaling.
How similar studies have performed: While the role of H2S in biology is gaining attention, the specific focus on zinc finger proteins in this context is relatively novel and has not been extensively tested.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Michel, Sarah L — University of Maryland Baltimore
- Study coordinator: Michel, Sarah L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.