Understanding how zinc finger proteins interact with hydrogen sulfide signaling
The Role of Zinc Fingers in H2S Signaling
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10689342
This study is looking at how a special type of protein called zinc finger proteins interacts with hydrogen sulfide, a gas that plays important roles in our bodies, to help us understand how it affects health and diseases like heart and brain conditions, which could lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10689342 on ClinicalTrials.gov |
What this research studies
This research investigates the role of zinc finger (ZF) proteins in the signaling process of hydrogen sulfide (H2S), a gasotransmitter involved in various biological functions. The study aims to uncover how H2S modifies ZF proteins, which are crucial for regulating gene expression and cellular functions. By analyzing the interaction between H2S and ZF proteins, the research seeks to clarify the mechanisms behind H2S signaling and its implications for diseases such as cardiovascular and neurological disorders. Patients may benefit from insights gained about how H2S influences health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular, neurological, inflammatory, or metabolic diseases.
Not a fit: Patients without these conditions or those not affected by H2S signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to H2S signaling.
How similar studies have performed: While the role of H2S in biology is gaining attention, this specific investigation into ZF proteins and H2S signaling is relatively novel.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MICHEL, SARAH L — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MICHEL, SARAH L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.