Understanding how Zika virus affects pregnancy and fetal development
Zika virus pathophysiology during pregnancy
This study is looking at how long the Zika virus stays in a pregnant woman's body and how that might affect the health of her baby, especially in terms of birth defects, to help doctors better support expectant moms who might be at risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10468066 on NIH RePORTER |
What this research studies
This research investigates the effects of Zika virus infection during pregnancy, focusing on how prolonged maternal viremia may influence the risk of congenital Zika syndrome in newborns. Using a nonhuman primate model, the study aims to understand the relationship between the duration of the virus in the mother and potential birth defects in the baby. The research will explore various factors that could affect this risk, including maternal immunity and other co-factors. By identifying these parameters, the study seeks to provide insights that could inform clinical interventions for pregnant women at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who have been exposed to Zika virus or are at risk of infection.
Not a fit: Patients who are not pregnant or those who have not been exposed to Zika virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of birth defects associated with Zika virus infection during pregnancy.
How similar studies have performed: Previous research has shown that understanding viral infections during pregnancy can lead to significant advancements in maternal and fetal health, suggesting potential for success in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: O'connor, David H. — University of Wisconsin-Madison
- Study coordinator: O'connor, David H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.