Understanding how Zika virus affects fetal development
JAK-STAT Control of Zika Virus-Induced Fetal Injury
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10668233
This study is looking at how the Zika virus affects babies during pregnancy, especially how it harms the brain and placenta, to help find ways to prevent and treat these issues for expecting moms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10668233 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of the Zika virus on fetal development, particularly focusing on how the virus interacts with placental and neural cells. By using advanced animal models, the study aims to uncover the mechanisms behind Zika virus-induced injuries, such as microcephaly and other congenital conditions. The research employs both in vivo and in vitro methods to evaluate the virus's impact and to test potential vaccines and treatments. This work is crucial for developing strategies to prevent and manage Zika virus infections during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who may be at risk of Zika virus infection, particularly those living in areas where the virus is prevalent.
Not a fit: Patients who are not pregnant or those who have already been infected with Zika virus and are not experiencing complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for pregnant women affected by Zika virus, ultimately reducing the incidence of congenital disabilities.
How similar studies have performed: Previous research on viral infections and their effects on fetal development has shown promising results, indicating that understanding these interactions can lead to effective interventions.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADAMS WALDORF, KRISTINA M. — UNIVERSITY OF WASHINGTON
- Study coordinator: ADAMS WALDORF, KRISTINA M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.