Understanding how Zfp719 mutations cause hearing loss in adults
Official title: Pathogenic mechanisms of adult hearing loss caused by Zfp719 mutations
Funded at University of Pennsylvania · NIH-10986857 · Data updated 2026-11-12
This study is looking into how certain gene changes, especially in the Zfp719 gene, might cause hearing loss in adults, and it aims to help people understand the genetic reasons behind this common issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $676,533 |
| NIH project number | 1R01DC021475-01A1 |
| Project ID | NIH-10986857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing unexplained hearing loss, particularly those with a family history of hearing issues.
✕Less likely to help
Patients with hearing loss due to non-genetic factors or those who do not have mutations in the Zfp719 gene may not benefit from this research.
What this research studies
This research investigates the genetic causes of adult-onset hearing loss, particularly focusing on mutations in the Zfp719 gene. By utilizing a genome-first approach and studying a biobank cohort, the researchers aim to identify rare genetic variants that contribute to hearing loss. They will also conduct functional studies in mice to explore the effects of these mutations on inner ear function. This work seeks to fill the knowledge gap regarding the genetic factors involved in hearing loss among adults, which is often overlooked compared to children.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for genetic hearing loss in adults.
How similar studies have gone: Other research has successfully identified genetic causes of hearing loss, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Epstein, Douglas J — University of Pennsylvania
- Study coordinator: Epstein, Douglas J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.