Understanding how zebrafish regenerate their heart tissue
Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regeneration
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10857232
This study looks at how adult zebrafish can heal their hearts with very little scarring and aims to learn how special cells help in this process, which could eventually lead to better heart repair treatments for people with heart damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10857232 on ClinicalTrials.gov |
What this research studies
This research investigates the unique ability of adult zebrafish to regenerate their heart with minimal scarring. It focuses on the role of polyploid cells, which have multiple copies of their genome, in the healing process after heart injury. By studying how these cells migrate and interact with other cells during regeneration, the research aims to uncover the mechanisms that could be applied to improve heart repair in humans. The findings could lead to new strategies for enhancing cardiac regeneration in patients with heart damage.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with heart conditions or injuries that could benefit from improved regenerative therapies.
Not a fit: Patients with non-cardiac conditions or those who do not have regenerative capabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in heart regeneration therapies for patients with heart disease.
How similar studies have performed: Other research has shown promising results in understanding tissue regeneration mechanisms in various organisms, suggesting potential for success in this area.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAO, JINGLI — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: CAO, JINGLI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.