Understanding how zebrafish fins regenerate and control their size
Ion signaling, cell transitions, and organ scaling during fin regeneration
This study is looking at how zebrafish can regrow their fins and what signals in their cells help control this process, which could help us understand how to improve healing and growth in human organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11039980 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind organ growth and regeneration using zebrafish fins as a model. It focuses on how bioelectric signals, particularly ion flows across cell membranes, influence the size and shape of regenerating tissues. By examining the role of specific ion channels and signaling pathways, the study aims to uncover how these factors contribute to the regeneration process and the maintenance of organ size. The findings could provide insights into congenital abnormalities and tissue repair in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to tissue regeneration or congenital abnormalities.
Not a fit: Patients with non-regenerative conditions or those unrelated to organ size control may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving tissue regeneration and addressing congenital abnormalities in humans.
How similar studies have performed: While the specific approach of using zebrafish for studying organ scaling is well-established, the exact mechanisms being explored in this research are novel and could provide new insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Stankunas, Kryn — University of Oregon
- Study coordinator: Stankunas, Kryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.