Understanding how ZCWPW1 affects the formation of sperm and eggs
Official title: The role of ZCWPW1 in meiosis
Funded at University of Michigan at Ann Arbor · NIH-10908447 · Data updated 2026-11-12
This study is looking at a protein called ZCWPW1 to see how it helps chromosomes work properly when making sperm and eggs, which is important for preventing issues like infertility and miscarriage, so that people trying to start a family can understand more about what might be affecting their chances.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $596,497 |
| NIH project number | 5R01GM148028-02 |
| Project ID | NIH-10908447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing infertility or recurrent miscarriages potentially linked to chromosomal issues.
✕Less likely to help
Patients with infertility not related to chromosomal abnormalities may not benefit from this research.
What this research studies
This research investigates the role of ZCWPW1, a protein that may influence how chromosomes pair and recombine during the formation of sperm and eggs. The study focuses on understanding how errors in chromosome segregation can lead to conditions like infertility and miscarriage. By examining the molecular mechanisms involved, the research aims to uncover how ZCWPW1 contributes to the proper functioning of meiosis, which is crucial for healthy reproduction. Patients may benefit from insights gained into the causes of chromosomal abnormalities that affect fertility.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility caused by chromosomal abnormalities.
How similar studies have gone: Other research has shown success in understanding chromosomal behavior during meiosis, but the specific role of ZCWPW1 in this context is still being explored.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hammoud, Saher Sue — University of Michigan at Ann Arbor
- Study coordinator: Hammoud, Saher Sue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.