Understanding how your genes affect HIV medicines
Pharmacogenomics of HIV Therapy
This project explores how a person's unique genetic makeup influences their response to HIV medications, aiming to make treatments more effective and reduce side effects for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11083096 on NIH RePORTER |
What this research studies
This project aims to understand why HIV treatments work differently for various individuals, particularly concerning side effects and how well the immune system recovers. Researchers are looking at how your genes might play a role in these differences, using advanced genetic tools like genome-wide association studies (GWAS) and polygenic risk scores (PRS) to find connections between your DNA and how you react to medicines. They also examine gene expression patterns in various body tissues to get a full picture of how your body processes HIV therapies. The ultimate goal is to find genetic clues that can help doctors choose the best and most personalized treatments for each patient.
Who could benefit from this research
Good fit: This research is relevant for individuals living with HIV who experience varying responses to current therapies, including those with side effects or incomplete immune recovery.
Not a fit: Patients who are not living with HIV or who are not receiving HIV therapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more personalized HIV treatments, helping doctors choose the right medications for each patient to improve effectiveness and minimize side effects.
How similar studies have performed: Genetic studies have shown promise in understanding drug responses for various conditions, and this project builds upon established methods to apply them specifically to HIV therapy.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Haas, David W — Vanderbilt University Medical Center
- Study coordinator: Haas, David W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.