Understanding how yellow fever affects humans
Determinants of yellow fever pathogenesis in humans
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10912720
This study is looking into why yellow fever can cause really serious symptoms in people, especially how the virus impacts our immune cells, with the goal of finding better treatments or vaccines to help those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10912720 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that contribute to the severe symptoms of yellow fever in humans, particularly focusing on how the virus affects immune cells and leads to complications like coagulopathy. The study aims to identify the cellular and molecular mechanisms involved in the disease's pathogenesis, which could help in developing better treatments or vaccines. By analyzing data from patients and using advanced techniques, the researchers hope to uncover why yellow fever is more severe in humans compared to animal models. This could ultimately lead to improved patient outcomes and public health strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with yellow fever or are at high risk of infection due to travel or living in endemic areas.
Not a fit: Patients who have not been exposed to yellow fever or those who have already received the yellow fever vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments and preventive measures for yellow fever, potentially saving thousands of lives each year.
How similar studies have performed: While there has been significant research on yellow fever, this specific approach focusing on immune cell involvement in pathogenesis is relatively novel and has not been extensively tested.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAILEY, ADAM LEE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BAILEY, ADAM LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.