Understanding how yeast chromosomes duplicate and stay stable
Chromosome structure, duplication and stability in yeast
This study looks at how yeast cells copy and keep their chromosomes stable, which is important for healthy cell division, and it aims to understand how small problems in DNA copying can affect cell health over time, with hopes that what we learn could help us understand similar issues in human cells related to cancer and growth disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11074032 on NIH RePORTER |
What this research studies
This research investigates the processes involved in the duplication and stability of chromosomes in yeast, which are crucial for accurate cell division. By examining the mechanisms that regulate the number and distribution of chromosomal origins, the study aims to uncover how mild disruptions in DNA replication can affect cell health and development over time. The research employs biochemical and molecular techniques to analyze the behavior of origin-binding proteins within different chromatin environments, which is essential for maintaining genomic integrity. Insights gained from this work could have implications for understanding similar processes in human cells, particularly in relation to cancer and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic predispositions to cancers or developmental disorders linked to chromosomal instability.
Not a fit: Patients with stable chromosomal conditions or those not affected by chromosomal replication issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of chromosome behavior, potentially informing new strategies for cancer treatment and prevention.
How similar studies have performed: Other research has shown success in understanding chromosomal behavior in model organisms, suggesting that this approach could yield valuable insights for human health.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Fox, Catherine a — University of Wisconsin-Madison
- Study coordinator: Fox, Catherine a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.