Understanding how yeast cells respond to arsenic exposure
The Arsenic Stress Signaling Code of Yeast
This study looks at how yeast cells respond to arsenic, a harmful substance found in the environment, to better understand how it affects cells and could help us learn more about its impact on human health and related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10632034 on NIH RePORTER |
What this research studies
This research investigates how yeast cells react to arsenic, a common environmental toxin, focusing on the cellular stress responses activated by different forms of arsenic. By studying the mechanisms through which arsenic influences cellular pathways, particularly the stress-activated MAPK Hog1, the research aims to uncover the biological processes that contribute to arsenic's toxicity and potential therapeutic effects. The findings could provide insights into how similar mechanisms might operate in human cells, especially in relation to diseases linked to arsenic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to arsenic through environmental sources and are at risk for related health issues.
Not a fit: Patients who have not been exposed to arsenic or do not have conditions related to arsenic toxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for diseases associated with arsenic exposure, including certain cancers and cardiovascular conditions.
How similar studies have performed: Previous research has shown that understanding stress responses in model organisms like yeast can provide valuable insights into human health, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Levin, David E. — Boston University Medical Campus
- Study coordinator: Levin, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.