Understanding how yeast cells divide chromosomes during reproduction
Meiotic recombination in budding yeast
This study looks at how yeast cells divide and sort their chromosomes, which is important for making sperm and eggs, to help us understand more about human reproduction and issues like infertility and genetic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11026436 on NIH RePORTER |
What this research studies
This research investigates the process of meiosis in budding yeast, which is crucial for the formation of gametes like sperm and eggs. It focuses on how chromosomes are properly sorted and segregated during cell division, a process that, if disrupted, can lead to infertility and genetic disorders such as Down Syndrome. By studying the mechanisms of meiotic recombination and the regulation of DNA repair, the research aims to uncover fundamental biological principles that could have implications for human reproduction. The methodology involves manipulating yeast cells to observe how they handle chromosome division and repair.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals facing infertility issues or those with a family history of chromosomal abnormalities.
Not a fit: Patients with conditions unrelated to chromosomal segregation or those not experiencing reproductive challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of infertility and genetic disorders, potentially informing new treatments or preventive measures.
How similar studies have performed: Other research has shown success in understanding meiotic processes in model organisms, suggesting that insights gained from this study could be applicable to human health.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Hollingsworth, Nancy M. — State University New York Stony Brook
- Study coordinator: Hollingsworth, Nancy M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.