Understanding how yeast cells divide and maintain genetic integrity
Official title: Saccharomyces cerevisiae microtubule and kinetochore dynamics
Funded at University of California Berkeley · NIH-11123087 · Data updated 2026-11-12
This study looks at how tiny structures in yeast cells help make sure chromosomes are divided correctly during cell division, which is important for keeping our genes healthy and could help prevent issues like cancer and birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | June 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $401,250 |
| NIH project number | 5R35GM149237-03 |
| Project ID | NIH-11123087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with a family history of cancer or congenital abnormalities.
✕Less likely to help
Patients with conditions unrelated to cell division or genetic integrity may not receive direct benefits from this research.
What this research studies
This research investigates the dynamics of microtubules and kinetochores in yeast cells, which are crucial for accurate chromosome segregation during cell division. By examining how these structures interact and function, the study aims to uncover the mechanisms that ensure genomic integrity and prevent conditions such as cancer and birth defects. The approach involves advanced biochemical assays to analyze the behavior of proteins involved in these processes. Patients may benefit from insights gained that could lead to improved cancer prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer and congenital defects by enhancing our understanding of cell division.
How similar studies have gone: Other research has shown success in understanding cell division mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Barnes, Georjana — University of California Berkeley
- Study coordinator: Barnes, Georjana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.