Understanding how YAP/TAZ affects skin aging and collagen maintenance
YAP/TAZ Regulation of Extracellular Matrix Homeostasis
This study is looking at how certain proteins in your skin help keep it healthy as you age, especially how skin cells that make collagen change over time, with the goal of finding ways to prevent or treat skin problems that come with getting older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10933560 on NIH RePORTER |
What this research studies
This research investigates the role of YAP/TAZ proteins in maintaining the extracellular matrix (ECM) of the skin, particularly as it ages. It focuses on how dermal fibroblasts, which produce collagen, change their behavior in response to the ECM environment. By examining the molecular mechanisms involved, the research aims to uncover why aged skin experiences a decline in collagen production and an increase in degradation. This could lead to insights into preventing or treating age-related skin conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing skin aging or related conditions.
Not a fit: Patients with acute skin injuries or conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve skin health and combat age-related skin diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular signaling pathways in skin health, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Fisher, Gary J — University of Michigan at Ann Arbor
- Study coordinator: Fisher, Gary J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.