Understanding how YAP1 helps blood vessel formation during organ healing
The role of YAP1 in angiogenesis during organ regeneration
This study is looking at a protein called YAP1 to see how it helps create new blood vessels, which is important for healing the lungs after surgery to remove one lung, and it hopes to find ways to use this knowledge to help people recover better after lung surgery or injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10444922 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called YAP1 in the formation of new blood vessels, which is crucial for the regeneration of organs, particularly the lungs. The study focuses on how YAP1 influences angiogenesis, the process of new blood vessel formation, after a surgical procedure called pneumonectomy, where one lung is removed. By using animal models, the researchers aim to uncover the mechanisms behind YAP1's action and how it can be harnessed to improve organ regeneration strategies. This could lead to new treatments that enhance recovery after lung surgery or injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have had lung surgery or suffer from conditions that impair lung function.
Not a fit: Patients with non-lung related health issues or those who have not undergone lung surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve lung regeneration and recovery in patients who have undergone lung surgery.
How similar studies have performed: Previous research has shown promising results in understanding angiogenesis and its role in organ regeneration, suggesting that this approach could yield significant insights.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Mammoto, Akiko — Medical College of Wisconsin
- Study coordinator: Mammoto, Akiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.