Understanding how YAP1 affects the development of blood cells
Official title: Investigating the role of YAP1 in blood cell specification
Funded at Temple Univ of the Commonwealth · NIH-10902643 · Data updated 2026-11-12
This study is looking at how a protein called YAP1 helps shape the early development of blood cells in embryos, which could lead to new ways to prevent blood-related birth defects.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $37,485 |
| NIH project number | 1F31HD113419-01A1 |
| Project ID | NIH-10902643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are expectant parents or families with a history of birth defects or blood disorders.
✕Less likely to help
Patients with established blood disorders or those not planning to conceive may not benefit from this research.
What this research studies
This research investigates the role of a protein called YAP1 in the early development of blood cells, particularly focusing on how it influences the formation of blood cell precursors during embryonic development. By examining the complex interactions between signaling pathways and gene expression, the study aims to uncover the mechanisms that lead to proper blood cell specification. The research utilizes advanced techniques like ATAC sequencing to analyze chromatin accessibility and gene regulation during critical stages of development. Insights gained from this research could lead to new strategies for preventing birth defects related to blood and vascular disorders.
Why it matters
Potential benefit: If successful, this research could provide new insights into preventing birth defects and improving treatments for blood-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of chromatin regulators in cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Abraham, Elizabeth — Temple Univ of the Commonwealth
- Study coordinator: Abraham, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.