Understanding how YAP and TAZ affect the aging ovary in women
Official title: Elucidating the Role of YAP and TAZ in the Aging Human Ovary
Funded at University of Nebraska Medical Center · NIH-10722368 · Data updated 2026-11-12
This study is looking at how two proteins, YAP and TAZ, affect the aging of ovaries and the health of egg-supporting cells in women over 40 who are trying to get pregnant through IVF, with the goal of finding ways to improve fertility as women age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $422,125 |
| NIH project number | 1R21HD112618-01 |
| Project ID | NIH-10722368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women aged 40 and older who are experiencing infertility and considering IVF.
✕Less likely to help
Patients who are younger than 40 or those not facing infertility issues may not benefit from this research.
What this research studies
This research investigates the role of two proteins, YAP and TAZ, in the aging process of the human ovary, particularly focusing on how they influence the function of granulosa cells, which are essential for healthy follicle development. The study aims to uncover the molecular mechanisms behind ovarian aging and infertility, especially in women over 40 who are undergoing in vitro fertilization (IVF). By analyzing the communication between oocytes and granulosa cells, the research seeks to identify how YAP and TAZ regulate these processes and contribute to fertility outcomes. This could lead to better understanding and potential interventions for age-related infertility.
Why it matters
Potential benefit: If successful, this research could provide insights that improve fertility treatments for older women, enhancing their chances of conception.
How similar studies have gone: Previous research has shown promising results in understanding the role of YAP and TAZ in cell function, suggesting that this approach could yield valuable insights into ovarian aging.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Davis, John S — University of Nebraska Medical Center
- Study coordinator: Davis, John S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.