Understanding how YAP affects heart regeneration
Official title: Cytoskeletal Control of Yap in Heart Regeneration
Funded at Baylor College of Medicine · NIH-10879099 · Data updated 2026-11-12
This study is looking at how a specific pathway in the body helps control a protein called YAP, which is important for heart cell health and healing, with the goal of finding new treatments for heart problems like heart failure that could help patients feel better and recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $662,113 |
| NIH project number | 5R01HL169511-02 |
| Project ID | NIH-10879099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from ischemic cardiomyopathy or heart failure.
✕Less likely to help
Patients with non-cardiac related conditions or those without heart failure may not benefit from this research.
What this research studies
This research investigates the role of the Hippo-signaling pathway in regulating YAP, a protein that influences heart cell function and regeneration. By studying how YAP is controlled through various modifications, the research aims to find new ways to treat conditions like ischemic cardiomyopathy and heart failure. The approach involves manipulating YAP's activity to enhance heart muscle cell repair and improve heart function. Patients may benefit from potential therapies developed from these findings that target YAP's role in heart regeneration.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve heart function and recovery in patients with heart failure.
How similar studies have gone: Previous research has shown promising results in manipulating YAP for heart regeneration, indicating a potential for success in this approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Martin, James F — Baylor College of Medicine
- Study coordinator: Martin, James F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.