Understanding how X chromosome inactivation affects substance use disorders in men and women
X chromosome inactivation in sex disparities to substance use disorder
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11099845
This study is looking at how men and women might experience substance use disorders differently, especially focusing on the X chromosome and how it could affect addiction, with the goal of finding better, personalized treatments for those struggling with substance abuse.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11099845 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in substance use disorders between sexes, focusing on how the X chromosome may influence these disparities. It aims to explore the role of X chromosome inactivation and how some genes escape this process, potentially affecting addiction behaviors. By utilizing advanced technologies and methodologies, the research seeks to uncover the underlying mechanisms that contribute to the increased vulnerability of females to substance abuse. The findings could provide insights into personalized treatment approaches for addiction based on genetic factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of substance use disorders, particularly females who may experience different effects compared to males.
Not a fit: Patients who do not have a history of substance use disorders or those who are not affected by sex-based disparities in addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for substance use disorders that take into account sex-based biological differences.
How similar studies have performed: While there has been some research on sex differences in addiction, this specific approach focusing on X chromosome inactivation is relatively novel and has not been extensively tested.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OGHUMU, STEVE ONYEKA — OHIO STATE UNIVERSITY
- Study coordinator: OGHUMU, STEVE ONYEKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder