Understanding how Wnt7a and ROR2 affect blood vessel formation in pulmonary arterial hypertension
The Wnt7a/ROR2 axis in the pathogenesis of pulmonary arterial hypertension
This research explores how specific signals, Wnt7a and ROR2, influence the growth of new blood vessels in people with pulmonary arterial hypertension, a serious lung condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11052546 on NIH RePORTER |
What this research studies
Pulmonary arterial hypertension (PAH) is a life-threatening condition where blood pressure in the lungs becomes dangerously high, often leading to heart failure. A key problem in PAH is that the tiny blood vessels in the lungs don't form correctly or are lost, which makes it harder for blood to flow. Our team is looking at how two important signals, Wnt7a and ROR2, work together to help create healthy new blood vessels. We believe that by understanding and potentially restoring these signals, we could improve blood vessel formation in PAH patients.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease mechanism in individuals affected by pulmonary arterial hypertension.
Not a fit: Patients without pulmonary arterial hypertension would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help restore healthy blood vessel growth in the lungs of patients with pulmonary arterial hypertension.
How similar studies have performed: Our previous work has shown that Wnt7a/ROR2 signaling is crucial for proper blood vessel formation and that this process is impaired in PAH patient cells.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: De Jesus Perez, Vinicio a — Stanford University
- Study coordinator: De Jesus Perez, Vinicio a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.