Understanding how Wnt5a-Ror signaling affects cell and tissue development
Function and regulatory mechanisms of the Wnt5a-Ror morphogenetic pathway
This study is looking at how a specific signaling pathway in our cells works and how changes in it can lead to developmental disorders like Robinow syndrome, with the hope of finding new ways to help patients by understanding how these signals affect growth and development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11009984 on NIH RePORTER |
What this research studies
This research investigates the Wnt5a-Ror signaling pathway, which plays a crucial role in the development and behavior of cells and tissues. By examining how this pathway is regulated and how mutations can lead to developmental disorders like Robinow syndrome, the research aims to uncover the biochemical mechanisms involved. Patients may benefit from insights gained about how these signals affect tissue elongation and development, potentially leading to new therapeutic strategies. The study employs advanced techniques in cell culture and molecular biology to explore these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Robinow syndrome or similar congenital disorders caused by mutations in the Wnt5a-Ror signaling pathway.
Not a fit: Patients with unrelated genetic conditions or those not affected by developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital disorders related to tissue development.
How similar studies have performed: Previous research has shown promising results in understanding similar signaling pathways and their implications in developmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Ho, Hsin-Yi Henry — University of California at Davis
- Study coordinator: Ho, Hsin-Yi Henry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.