Understanding how WNT signaling helps nerve repair cells form after injury
Official title: WNT Mediated Induction of Schwann Cell Plasticity
Funded at University of California Los Angeles · NIH-10985353 · Data updated 2026-11-12
This study is looking at how certain signals in the body help special cells called Schwann cells change into repair cells after a nerve injury, which could lead to new ways to help people heal from nerve damage.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $210,600 |
| NIH project number | 1K01NS134780-01A1 |
| Project ID | NIH-10985353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from peripheral nerve injuries or disorders affecting motor function and pain sensitivity.
✕Less likely to help
Patients with non-peripheral nerve related conditions or those whose nerve injuries are not amenable to cellular repair may not benefit from this research.
What this research studies
This research investigates the role of WNT signaling in the transformation of Schwann cells into repair cells following peripheral nerve injury. By examining how these cells adapt their functions to support nerve recovery, the study aims to uncover the molecular mechanisms involved in this process. Utilizing advanced genetic and viral tools, researchers will analyze how different signaling pathways contribute to the formation and function of these repair cells. This could lead to new therapeutic targets for treating nerve injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with peripheral nerve injuries, enhancing recovery and function.
How similar studies have gone: Previous research has shown promising results in understanding nerve repair mechanisms, but the specific role of WNT signaling in Schwann cell transdifferentiation is still being explored.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Daboussi, Lydia — University of California Los Angeles
- Study coordinator: Daboussi, Lydia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.