Understanding how Wnt signaling affects stomach stem cells
Wnt Pathway Regulation of Gastric Stem Cell Function
This study is looking at how a specific signaling process in the body affects stomach stem cells in people with familial adenomatous polyposis (FAP), a genetic condition that causes unusual growths in the stomach and intestines, to help find better ways to manage and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11009570 on NIH RePORTER |
What this research studies
This research investigates the role of Wnt signaling in regulating gastric stem cells, which are crucial for maintaining the health of stomach tissue. It focuses on patients with familial adenomatous polyposis (FAP), a genetic condition that leads to abnormal growths in the stomach and intestines due to mutations in the APC gene. By studying how Wnt signaling influences cell proliferation in different regions of the stomach, the research aims to uncover mechanisms behind gastric polyp formation. This could provide insights into better management and treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with familial adenomatous polyposis (FAP) who are at risk for gastric polyps and related complications.
Not a fit: Patients without familial adenomatous polyposis or those not experiencing gastric issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for gastric polyps and cancers in patients with familial adenomatous polyposis.
How similar studies have performed: Previous research has shown that understanding Wnt signaling pathways can lead to significant advancements in treating gastrointestinal disorders, suggesting potential success for this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Samuelson, Linda C. — University of Michigan at Ann Arbor
- Study coordinator: Samuelson, Linda C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.