Understanding how Wnt proteins are transported in cells
Official title: Molecular Mechanisms of Wnt Transport
Funded at Columbia University Health Sciences · NIH-10930887 · Data updated 2026-11-12
This study is looking at how Wnt proteins, which help cells talk to each other and grow, move around inside cells and how they work with certain transport proteins, with the hope that understanding this process better could help us learn more about diseases like bowel cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $444,705 |
| NIH project number | 5R01CA275005-02 |
| Project ID | NIH-10930887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by conditions related to Wnt signaling, such as bowel cancer.
✕Less likely to help
Patients with conditions unrelated to Wnt signaling or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the transport of Wnt proteins, which are crucial for cell communication and development. The study focuses on how Wnt proteins are modified and transferred within cells, particularly how they interact with specific transport proteins. By utilizing advanced imaging techniques like cryo-electron microscopy, researchers aim to uncover the structural details of these interactions. This knowledge could lead to better understanding of various diseases, including bowel cancer, where Wnt signaling may play a role.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to Wnt signaling, potentially improving treatment options for patients.
How similar studies have gone: While the specific mechanisms of Wnt transport are still being explored, related research has shown promise in understanding cell signaling pathways, indicating potential for success in this area.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Mancia, Filippo — Columbia University Health Sciences
- Study coordinator: Mancia, Filippo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.