Understanding how WNK1 influences blood cell production during infections
Official title: WNK1-dependent macropinocytosis mediates emergency myelopoiesis
Funded at Sloan-Kettering Inst Can Research · NIH-10985750 · Data updated 2026-11-12
This study is looking at how a protein called WNK1 helps your body make more blood cells, especially during infections when you need extra immune cells, and it aims to find ways to improve treatments for serious conditions like sepsis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,431 |
| NIH project number | 1K99HL171844-01A1 |
| Project ID | NIH-10985750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect blood cell production or those experiencing severe infections.
✕Less likely to help
Patients with stable blood cell counts and no history of infections may not benefit from this research.
What this research studies
This research investigates the role of the WNK1 protein in the production of blood cells, particularly during infections when the body needs to rapidly increase immune cell numbers. It focuses on how myeloid progenitor cells, which are responsible for producing various types of blood cells, respond to signals that direct their development into specific immune cells like neutrophils. By studying these processes, the research aims to uncover the mechanisms that regulate blood cell production in response to infection, which could lead to better treatments for conditions like sepsis.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for infections and conditions that require enhanced immune responses.
How similar studies have gone: Other research has shown promising results in understanding blood cell production mechanisms, but the specific role of WNK1 in this context is relatively novel.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Trzeciak, Alissa Jane — Sloan-Kettering Inst Can Research
- Study coordinator: Trzeciak, Alissa Jane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.