Understanding how white blood cells move through blood vessels during inflammation
Transendothelial Migration of Leukocytes: Developing New Paradigms in Health and Disease
['FUNDING_OTHER'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11049150
This study is looking at how white blood cells move through blood vessel walls during inflammation, with the goal of finding new ways to help control inflammation and improve treatments for people with inflammatory diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11049150 on ClinicalTrials.gov |
What this research studies
This research investigates the process of transendothelial migration (TEM), where white blood cells (leukocytes) move through the lining of blood vessels during inflammation. By studying the molecules and mechanisms that regulate this process, the research aims to develop new therapeutic strategies to control inflammation. The approach includes both in vitro and in vivo models to explore how leukocytes interact with endothelial cells, which line the blood vessels. The findings could lead to better treatments for various inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory diseases or conditions that involve abnormal leukocyte migration.
Not a fit: Patients with acute, non-inflammatory conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively manage inflammation-related conditions.
How similar studies have performed: Previous research has shown promising results in understanding leukocyte migration, indicating that this approach has the potential for significant advancements.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULLER, WILLIAM A — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: MULLER, WILLIAM A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.