Understanding how West Nile virus infects the lymphatic system
Official title: Defining West Nile virus infection of the lymphatics using single cell techniques
Funded at Emory University · NIH-11131230 · Data updated 2026-11-12
This study is looking at how the West Nile virus affects the lymphatic system and spleen by examining individual cells, which could help us understand how the body fights the virus and lead to better treatments or vaccines for those who get infected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 3, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $273,000 |
| NIH project number | 5R21AI186306-02 |
| Project ID | NIH-11131230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with or are at risk for West Nile virus infection.
✕Less likely to help
Patients who are not at risk for West Nile virus or those who have already developed severe neurological complications may not benefit from this research.
What this research studies
This research investigates how the West Nile virus (WNV) infects the lymphatic system and spleen using advanced single cell techniques. By examining the cellular interactions and immune responses at a single cell level, the study aims to identify the specific cells targeted by the virus and how the body attempts to control the infection. This approach could provide valuable insights into the mechanisms of virus-induced encephalitis and the body's antiviral responses. The findings may lead to the development of new antiviral therapies or vaccines.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments or vaccines for West Nile virus infection.
How similar studies have gone: Previous research has shown success in understanding other arboviral infections using similar single cell techniques, indicating potential for breakthroughs in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Suthar, Mehul Shamal — Emory University
- Study coordinator: Suthar, Mehul Shamal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.