Understanding how West Nile virus infects cells in the body
Identification of the initial cells infected by West Nile virus ex vivo and in vivo
This study is looking at how the West Nile virus affects our body's cells and immune system after getting bitten by a mosquito, so we can better understand how to create vaccines and treatments for it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10881899 on NIH RePORTER |
What this research studies
This research investigates how the West Nile virus (WNV) infects cells in the human body, particularly focusing on the immune response and the types of cells that are initially infected. By using advanced laboratory techniques, the researchers aim to identify the specific immune cells that the virus targets after it enters the body through a mosquito bite. The study employs both ex vivo models and engineered viral strains to observe the infection process and the immune response in a controlled environment. This knowledge is crucial for developing effective vaccines and treatments for WNV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to West Nile virus or are at risk of infection, particularly those living in areas with high mosquito populations.
Not a fit: Patients who are not at risk of West Nile virus infection or those with pre-existing immunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of vaccines or antiviral treatments for West Nile virus, improving patient outcomes.
How similar studies have performed: Previous research has shown success in understanding viral infections through similar methodologies, but this specific approach to WNV is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lim, Jean Kyou — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lim, Jean Kyou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.