Understanding how well vaccines work against respiratory viruses in real-world settings
Official title: RFA-IP-22-004, Multidisciplinary Approach to Understanding Vaccine Efficacy and Transmission of Viral Respiratory Tract Infections in the Real World
Funded at Washington University · NIH-10909767 · Data updated 2026-11-12
This study is looking at how well flu and COVID-19 vaccines work for people with respiratory infections, and it’s for anyone who wants to understand more about vaccine protection in real-life situations.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,900,000 |
| NIH project number | 5U01IP001182-03 |
| Project ID | NIH-10909767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals experiencing acute respiratory illnesses who are seeking outpatient care.
✕Less likely to help
Patients who are not currently experiencing respiratory infections or those who have already been vaccinated may not benefit from this research.
What this research studies
This research investigates the effectiveness of vaccines against influenza and SARS-CoV-2 in patients experiencing respiratory infections. By employing a multidisciplinary approach, the study aims to recruit a diverse group of ambulatory patients using automated alerts and advanced data collection methods. The research team, composed of experts from various fields, will analyze samples and data to assess how well these vaccines protect against these viral infections in everyday situations. The findings will help inform public health strategies and improve vaccine deployment.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies that enhance protection against respiratory viruses for the general population.
How similar studies have gone: Previous research has successfully utilized similar multidisciplinary approaches to assess vaccine effectiveness, indicating a promising potential for this study.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: House, Stacey — Washington University
- Study coordinator: House, Stacey
Related research
Other NIH-funded projects on the same topics.
-
Enhanced primary care telemedicine for kids with lung and airway infections
A pediatric-focused telemedicine program is being studied to reduce unnecessary antibiotic use for common respiratory infections in children.
-
Understanding how vaccines work in real life against flu and COVID-19
A real-world study at a major university hospital will track how well flu and COVID-19 vaccines protect ambulatory patients who have respiratory infections.
-
How flu and COVID-19 vaccines protect people seen in outpatient clinics
This project measures how well influenza and COVID-19 vaccines protect people who come to outpatient clinics with respiratory symptoms.
-
Using telemedicine to improve antibiotic prescribing for respiratory infections
This study is looking at how virtual doctor visits can help people with respiratory infections get the right treatment and avoid unnecessary antibiotics, making it easier for everyone to stay healthy.
-
Understanding infections in children with tracheostomies
This study is looking at what causes respiratory infections in children with tracheostomies, so we can better understand which kids might get sick more often and help them stay healthier.
-
Understanding how certain immune cells affect severe viral lung infections in children
This study is looking at how certain immune cells in kids with severe viral lung infections might be making it harder for their bodies to fight off the illness, with the hope of finding new ways to help them recover better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.