Understanding how weight loss surgery improves heart and diabetes health
Defining the pathways of cardiometabolic health after weight loss
This study looks at how weight loss surgery, especially the Roux-en-Y gastric bypass, can help improve heart health and lower the risk of diabetes by examining changes in hormones and gut bacteria, and it’s for people who have had this type of surgery to help understand how these changes can benefit their long-term health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11063099 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind improved heart health and reduced diabetes risk following weight loss surgery, particularly focusing on the Roux-en-Y gastric bypass procedure. By studying changes in hormones, bile acids, and gut microbiome, the research aims to identify the biological pathways that contribute to better cardiometabolic health after surgery. Patients who have undergone weight loss surgery will be monitored to understand how these changes affect their long-term health outcomes. The findings could lead to new treatments or interventions for obesity-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone Roux-en-Y gastric bypass surgery or are considering weight loss surgery.
Not a fit: Patients who are not overweight or do not have obesity-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cardiovascular disease and Type 2 diabetes in patients who are overweight or obese.
How similar studies have performed: Previous research has shown promising results in understanding metabolic changes after weight loss surgery, indicating that this approach has potential for significant insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Thaker, Vidhu V. — Columbia University Health Sciences
- Study coordinator: Thaker, Vidhu V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.