Understanding how we learn and remember new information over time and during sleep

Learning novel structure across time and sleep

NIH-funded research University of Pennsylvania · NIH-11041178

This study is looking at how our brains learn and remember new places, like when you explore a new city, and it’s for anyone curious about how memory works, especially how sleep helps us remember things better.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11041178 on NIH RePORTER

What this research studies

This research investigates how the brain, particularly the hippocampus, learns and retains new information about our environment, such as navigating a new city. It uses advanced imaging techniques like functional MRI to observe brain activity while participants engage in tasks that require them to integrate information from different experiences. The study aims to clarify how our brains encode and store this information, especially during sleep, which may play a crucial role in memory consolidation. By developing a neural network model, the research seeks to enhance our understanding of the mechanisms behind learning and memory.

Who could benefit from this research

Good fit: Ideal candidates for participation would include individuals experiencing memory difficulties or those interested in understanding memory processes.

Not a fit: Patients with severe cognitive impairments or those unable to participate in fMRI procedures may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for enhancing memory and learning, potentially benefiting individuals with memory impairments.

How similar studies have performed: Previous research has shown promising results in understanding memory processes through similar imaging techniques, indicating that this approach has potential for success.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.