Understanding how water channels affect cell movement
Exploring mechanisms of aquaporin-mediated cell migration
['FUNDING_OTHER'] · UNIV OF MARYLAND, COLLEGE PARK · NIH-10895306
This study is looking at how tiny water channels in our cells help them move around, especially in the brain, to better understand how this movement works in both healthy and sick people, which could lead to better treatments and drug delivery.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MARYLAND, COLLEGE PARK (nih funded) |
| Locations | 1 site (COLLEGE PARK, UNITED STATES) |
| Trial ID | NIH-10895306 on ClinicalTrials.gov |
What this research studies
This research investigates the role of aquaporins, which are water channels in cell membranes, in regulating how cells migrate. By using advanced bioengineering techniques and in vitro models, the team will explore how mechanical forces and cell interactions influence cell movement, particularly at the blood-brain barrier. The research aims to uncover the mechanisms behind cell adhesion and migration, which are crucial for understanding various health conditions and improving drug delivery methods. Patients may benefit from insights gained about how these processes work in both healthy and diseased states.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve altered cell migration, such as cancer patients or those with neurological diseases.
Not a fit: Patients with stable conditions that do not involve cell migration or those who are not affected by the blood-brain barrier may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions involving cell migration, such as cancer metastasis and neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding cell migration mechanisms, but the specific focus on aquaporins in this context is relatively novel.
Where this research is happening
COLLEGE PARK, UNITED STATES
- UNIV OF MARYLAND, COLLEGE PARK — COLLEGE PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STROKA, KIMBERLY — UNIV OF MARYLAND, COLLEGE PARK
- Study coordinator: STROKA, KIMBERLY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.