Understanding how WASL signaling affects bone development
Official title: A novel role for Wasl signaling in the regulation of skeletal patterning
Funded at Boston Children's Hospital · NIH-11082477 · Data updated 2026-11-12
This study is looking at how a specific signaling process called WASL helps shape bones and cartilage, using zebrafish and mice to learn more about it, which could eventually help people understand and treat issues related to bone development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $534,195 |
| NIH project number | 5R01HD112906-03 |
| Project ID | NIH-11082477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with skeletal abnormalities or genetic conditions affecting bone development.
✕Less likely to help
Patients with unrelated health issues or those not affected by skeletal development disorders may not receive any benefit from this research.
What this research studies
This research investigates the role of WASL signaling in the development of skeletal structures. By using advanced models in zebrafish and mice, the study aims to uncover how WASL influences the formation of bones and cartilage, which is crucial for proper skeletal patterning. The research will explore both the actin-dependent and independent functions of WASL, providing insights into how disruptions in this signaling pathway may lead to developmental abnormalities. Patients may benefit from a better understanding of conditions related to skeletal development and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for skeletal development disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of signaling pathways in skeletal development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Harris, Matthew P — Boston Children's Hospital
- Study coordinator: Harris, Matthew P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.