Understanding how VPS13D protein affects nerve cell health
Official title: Investigation of the Lipid Transfer ProteinVPS13D at the Golgi Apparatus
Funded at Yale University · NIH-11065822 · Data updated 2026-11-12
This study is looking at a protein called VPS13D that helps keep nerve cells healthy, and it's for anyone interested in understanding how problems with this protein might be linked to neurodegenerative diseases like spastic ataxia, with the hope of finding new ways to help.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 16, 2025 |
| Project end | January 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS135930-01A1 |
| Project ID | NIH-11065822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those exhibiting symptoms of spastic ataxia.
✕Less likely to help
Patients with neurodegenerative diseases not linked to VPS13D or those without neurological symptoms may not benefit from this research.
What this research studies
This research investigates the VPS13D protein, which plays a crucial role in the health of nerve cells by facilitating lipid transfer within cellular membranes. The study aims to explore how VPS13D functions at the Golgi apparatus, a key organelle involved in processing and transporting proteins and lipids. By using cellular models, researchers will examine the localization and interactions of VPS13D to better understand its role in neurodegenerative diseases like spastic ataxia. The findings could provide insights into the mechanisms of these diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases associated with VPS13D dysfunction.
How similar studies have gone: Previous studies have shown promising results in understanding lipid dynamics in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Amos, Chase Allen — Yale University
- Study coordinator: Amos, Chase Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.